Asymmetric Michael Addition of Carbonyl Compounds to Nitro-olefins Catalyzed by Simple Organocatalysts

  • Asymmetric Michael addition of carbonyl compounds to nitro-olefins is one of the important carbon carbon bond forming reactions and especially so when quaternary stereogenic carbons are formed. Over the past decade a large number of organocatalysts have been developed for the asymmetric Michael addition of carbonyl compounds to nitro-olefins. Impressive results have been obtained but many parameters require improvement. For example, stereo inductions, catalyst loading, stoichiometry of starting materials, reaction time, limited substrate scope, etc. I focused on improving these parameters by designing new organocatalysts that incorporated old concepts from outside the field and by introducing new templates based on known concepts from within the field. This manifested itself in a two-prong approach: 1) tertiary-primary diamines and 2) assembled catalysts. The assembled catalysts were found to be superior for the intended goal.

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Publishing Institution:IRC-Library, Information Resource Center der Jacobs University Bremen
Granting Institution:Jacobs Univ.
Author:Mohammad Shoaib
Referee:Muhammad Afzal Subhani, Thomas Nugent, Nikolai Kuhnert
Advisor:Thomas Nugent
Persistent Identifier (URN):urn:nbn:de:101:1-2013052812413
Document Type:PhD Thesis
Language:English
Date of Successful Oral Defense:2011/02/11
Date of First Publication:2011/03/28
PhD Degree:Chemistry
School:SES School of Engineering and Science
Library of Congress Classification:Q Science / QD Chemistry / QD241-441 Organic chemistry
Other Countries Involved:Pakistan
Call No:Thesis 2011/8

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